Secretary of State James Blaine
When Benjamin Harrison was elected President in 1888, he invited Blaine to become Secretary of State once again. In 1889, a Pan American Congress was finally convened in Washington. Blaine followed up by campaigning tirelessly for arbitration treaties with Latin American nations and for Congressional authority to negotiate trade agreements on the basis of reciprocity. Blaine's "spirited foreign policy" also included settlement of a dispute with Germany and Great Britain over the Samoan Islands, long-running negotiations with Great Britain over the right of Canadian vessels to hunt seals in the Bering Sea, and resolution of serious disputes with Chile and Italy over the murder of American citizens. Blaine's major accomplishment in his second tenure as Secretary was the promotion of closer political and commercial relations between the United States and the nations of Latin America. But even here these good feelings began to deteriorate with rising jingoism in the United States, which stirred latent Latin American suspicions of the "Colossus of the North." Whether because of worsening relations with President Harrison, deteriorating health, or ambition to again secure the Republican nomination for the presidency, Blaine resigned in June 1892. James G. Blaine, "the man from Maine," died in January 1893 at age 63.

